Landmark Research

Publications

Ovarian support cell in vitro maturation (OSC-IVM) results in healthy murine live births with no evidence of reprotoxicology in a multigenerational study
Road to in vitro maturation (IVM), from basic science to an informed clinical practice
Clinical procedures for in vitro maturation treatment
Donor side effects experienced under minimal controlled ovarian stimulation (COS) with in vitro maturation (IVM) versus conventional COS for in vitro fertilization (IVF) treatment
Rescue in vitro maturation using ovarian support cells of human oocytes from conventional stimulation cycles yields oocytes with improved nuclear maturation and transcriptomic resemblance to in vivo matured oocytes
Reproducible differentiation of pure ovarian support cells from clinical-grade hiPSCs as a novel infertility treatment
Human-induced pluripotent stem cell-derived ovarian support cell co-culture improves oocyte maturation in vitro after abbreviated gonadotropin stimulation
Improved rescue of immature oocytes obtained from conventional gonadotropin stimulation cycles via human induced pluripotent stem cell-derived ovarian support cell co-culture
Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression
Towards reconstituting an ovary
Efficient Human Germ Cell Specification from Stem Cells via Combinatorial Expression of Transcription Factors
Expanding homogeneous culture of human primordial germ cell-like cells maintaining germline features without serum or feeder layers
An integrated pipeline for mammalian genetic screening

Abstracts & Posters

Characterization of the hormonal profiles during minimal stimulation protocols in normal responder women and the assessment of their pain level after oocyte retrieval
Comparing Different Mini-Stimulations and the Retrieval Efficiency for Obtaining Immature Oocytes for In Vitro Maturation
Human induced pluripotent stem cell-derived ovarian support cells improve the maturation rate of immature human oocytes in vitro
Improvement in rescue in vitro maturation outcomes using co-culture with induced pluripotent stem cell-derived ovarian support cells
In vitro matured oocytes co-cultured with human induced pluripotent stem cell-derived ovarian support cells display transcriptomic quality similar to in vivo matured oocytes
Ovarian support cells derived from human induced pluripotent stem cells allow in vitro maturation of oocytes and embryo development in a mouse model
An optimized approach to generate ovarian support cells from induced pluripotent stem cells: a platform to develop therapeutics for diseases of the female reproductive system
Ovarian support cell lines differentiated from human induced pluripotent stem cells: multi-omics characterization of a platform to develop therapeutics for diseases of the female reproductive system
Investigation of transcription factor function via in vitro recapitulation of human oogenesis